Yaniko lazily kicks over a glass jar she used as an ashtray and then throws her spent cigarette out the window, burning the Landlord's head. An unemployed Mankasu feels self-conscious about buying a crepe. Yakuko has a breakdown after being fired from her last job. Hameko becomes blinded by rage after losing an online match until Yakuko knocks her down. Mankasu talks with the Landlord about drawing a Beastfolk femboy for her next project, and gets Shunran to model her idea. After visiting her sister, Imoko comes across Aruko and starts taking care of her. When Kaoruko comes back home, Imoko mistakes her for Aruko's mother, and start berating her. Yomuko models a bikini for Mankasu while asking for more writing advice. However, she accidentally gets Mankasu in trouble when she steps outside while still wearing the bikini. Yaniko and the Landlord get in a fight after accusing each other of being lazy. Yaniko accidentally mixes up her beer cans full of beer and ones full of cigarette butts.

Shizue tries to smoke in a café that only allows e-cigarettes while Imoko is on a class trip to Kyoto. Imoko's friends come up with ideas to "improve" Kyoto while viewing the Nyankakuji Golden Pavilion. Meanwhile, Mankasu takes the other apartment residents to Kyoto. Mankasu draws consecutive bad fortunes at a temple while splurging on the trip. Elsewhere, the Landlord watches a ghost special on TV, and feeling lonely, sleeps with his sex doll. The next day, Imoko and Yomuko come across several discarded cigarette butts while taking a "tour of the anus" of the Cat Buddha, unaware that Yaniko's group already passed through earlier. Imoko's class learns about the relationship the Beastfolk had with humans in Japan during the Edo period, including the Boshin War. Mankasu's group visits Nara Park, as Yaniko meets an intelligent sika deer who explains own people's history. He then laments both the downfall of his people and how his intelligence is slowly slipping away. Mankasu finds out that her manga has been canceled while she is driving the group back to the apartment building, which causes her to flip the car. Once they return home, Mankasu goes stir-crazy without a steady job.

Shizue enjoys the smell of used cigarettes with Yaniko. Yakuko drives to the Suisha Waterfall with Hameko while Hameko livestreams the trip. An annoyed Yakuko accidentally speeds off without her. Hameko goes hitchhiking, but becomes aghast at a driver refusing to let her out until he takes pictures of her mouth. Yakuko soon returns to pick her up. Yaniko returns to the apartment building after a dog-walking job, and gives the Landlord a bag of dog poop, which he erroneously believes is Valentine's Day chocolate. Yaniko takes down a kite in revenge for it snatching her hot dog, but the Landlord pays her to let it go. He later fantasizes about the kite coming back in Beastfolk form to thank him. A burnt out Mankasu dresses up in a lewd magical girl outfit. The Landlord then shows up and is aroused when he sees her wearing cat ears. Penpenneko hangs out in Aruko's room while the latter is asleep. However, she is forced to hide on the ceiling when the Landlord walks in. After Yaniko and Kaoruko tell bad jokes to each other on April Fools' Day, Yaniko fakes a pregnancy with Shunran as the father to prank Imoko.

Yaniko sets off the sprinkler system after she ignores a janitor's warning not to smoke in a public bathroom. Imoko's classmate, Ouji Ruko, wants to get closer to her. However, she gives Imoko a disgusting gift after getting vague hints from her friends. Yaniko tries to grab another smoke while she is not finished using the toilet. Kaoruko struggles to get a laugh from her friends again, and accidentally embarrasses herself in front of a visiting Imoko. A human family holds a "Beastfolk Funeral" for their deceased relative. Yakuko and Kaoruko go clothes shopping for Yaniko. Yakuko tests a hypnosis app on Yaniko to get her to stop smoking, but it works too well and the hypnotized Yaniko spits on smokers in a crusade against smoking. Imoko and Yomuko's class get their report cards, and the two later become friends when Imoko asks for Yomuko's help with writing assignments. Shizue indulges in chainsmoking while Imoko is out of the house. However, when Imoko comes home early, Shizue makes up a story about being burglarized, which backfires on her when Imoko swears she is never going to spend the night away ever again.

Yaniko celebrates her birthday alone, unaware her friends are throwing her a surprise party at a nearby bar, as no one remembered to invite her there. Hameko is visited by a catboy named Shunran, who pretends to be Kaoruko's lover, until Kaoruko herself steps in and reveals that Shunran is her younger brother. Kaoruko steps outside of a social gathering and chats with a classmate, soon getting embarrassed by a returning Yaniko. Yomuko expresses admiration for Mankasu after saving one of her manga pages. Yakuko and Kaoruko set up a smoking area out of snow while Yaniko sleeps. The drunken catgirls at the apartment play a prank on the Landlord. The Landlord hosts a mochitsuki at the apartment for the New Year, but gets stuck in a time loop where one of the catgirls somehow dies during the mochi pounding, until he takes drastic measures to break the loop, saving his tenants from death but getting himself arrested for indecent exposure. Kaoruko and Shunran visit their family's home for the holidays.

Yaniko unknowingly summons the Nicotine Demon while she is sleeping. However, he is so disgusted by her repulsive lifestyle that he returns home. Yaniko gets a temp job scrubbing old factory pipes and ignores the warning not to smoke after handling flammable materials, sparking a huge explosion. Yakuko returns after attending her grandfather's memorial service and suggests to Yaniko on visiting her family. Yaniko shares cigarettes with her mother, Shizue, who tries to hide her habit from Imoko even when the family goes out to see a movie. Imoko saves Aruko from stepping into traffic while she is distracted from her recent diagnosis. Aruko's tremors make the entire apartment building shake. The Landlord accidentally gets stuck outside while having another session with his sex doll, and has to rely on Mankasu to get back inside without anyone else seeing him. Yomuko visits Yaniko again to get feedback on her story. The Landlord offers solace to Penpenneko until a gust of wind lifts up her outfit, leading to the Landlord having an erection. Mankasu gets too excited while brushing Yaniko's hair. As a result, Yaniko accidentally becomes bald.

Yaniko takes creative measures to continue smoking through the night. Aruko chugs sake and wanders off from the party. She then takes a cab all the way to Enoshima until the Landlord and Yakuko track her down with a GPS device hidden in her hair and bring her back home. While hanging out in Aruko's room, the catgirls find all the things they planted in Aruko's massive hairdo until a lit cigarette sets her alcohol-soaked hair on fire. Yomuko asks Mankasu for advice on time management, but Mankasu notices she spends her time browsing "Nyax". A flashback shows the Landlord and Yakuko chatting with each other while tracking down Aruko. Mankasu gets frustrated with her new temp assistants while trying to hit a deadline. Penpenneko talks about living with nature and gets bitten by a black cat. Penpenneko later takes shelter from the storm in Yaniko's room, but rushes back outside when she sees her tent and belongings have been swept away in the Nyagami River. Yaniko smokes from a sparkler on the beach.

moko confiscates her sister's cigarettes. However, just as she starts to feel guilty, she walks in on Yaniko pulling out a fresh pack she hid in her stomach earlier. Imoko turns down a nice boy named Shu when he confesses his feelings for her. It is later implied that thanks to her sister, Imoko has a preference for those who need to be taken care of. Yakuko has a Pavlovian response to the number 12. The catgirls at the apartment play an old version of The Game of Life, from when beastfolk were more openly discriminated against. Yakuko goes hunting for stag beetles, in which only Yaniko has time to accompany her. Yakuko, Yaniko, and Hameko visit the Tobacco Village, home of the Alpha, an ancient beastfolk tribe that live in the mountains, run by Chief Lani. While Lani explains her tribe's history and customs, Yaniko insults her tribal tattoos. In response, Lani makes the trio jump off their tower while hanging by a vine. Hameko wets herself while falling, earning her the nickname of "Rainbow Maker". Imoko feels too self-conscious after catching a cicada with her catlike reflexes.

Yaniko decides to finish her cigarette before saving a drowning child. Imoko sees a cigarette butt in her burger and is horrified, thinking Yaniko has been turned into a meat patty. In reality, Yaniko accidentally dropped her cigarettes into the food. Yaniko assists her manga artist neighbor, Mankasu, and accidentally burns through a page. A few days later, Yaniko models as a schoolgirl for Mankasu's erotic manga in public, but they are both arrested for suspicious activity. Mankasu gets Kaoruko as a replacement. At a mahjong parlor, intimidating chief editor of Nyan Magazine Kazushi and his bodyguards are turned on by Yaniko and Hameko. Aspiring writer Yomuko visits Yaniko to ask for advice on her novel. A rival gangster family shoots Kazushi at the office of Nyan Magazine to avenge an insult, but Kazushi survives thanks to hiding an issue of Afternyan with a Land of the Lustrous special insert under his robe. However, one of the bullets pierces through and delivers a near-fatal wound, until Yaniko's touch gives him the will to live. Hameko streams life around the apartment, but candid footage of its residents and the Landlord gets her Hame Channel suspended.

Yaniko plays soccer with some kids in the park only to be fined by police officers. Yaniko drops increasingly disgusting things on the Landlord's head, but goes too far when she slaps a pair of human-toxic nicotine patches on him. The Landlord tasks Yaniko with weeding the yard to disastrous results. Yaniko finds mysterious talismans in her room and hears ominous noises. Yaniko tries to ask the Landlord on its source, but the embarrassed Landlord, having been interrupted from his session with a sex doll, refuses to explain. Kaoruko attempts to make Yaniko laugh to no avail. Yaniko visits Aruko's room for a free drink. Aruko pukes in her sleep. Yaniko lets out a massive fart inside a broadcast van, which Kaoruko gleefully broadcasts. Yaniko gets stuck halfway through a wall trying to reach a dropped cigarette, and Kaoruko's efforts to free her get misinterpreted as public sex.

Yaniko has a hallucination of a talking cigarette while going through withdrawal. Yaniko bums a smoke off her neighbor, Yakuko, who insists she is smoking a normal cigarette. Yaniko walks in on Yakuko while she is injecting herself with an unknown substance. Yaniko and Yakuko come across a fortune-teller in an alleyway, who predicts that Yaniko only has five years left to live. Yakuko looks up to Yaniko, but is humbled when Yaniko later wakes her up to beg for cigarette money. Yaniko hangs out in Hameko's room, only for Hameko to get increasingly mad at both the game and her. Imoko gets embarrassed by her older sister while walking home from school with her friends. Hameko accidentally livestreams herself eating a bug. Yakuko remembers Hameko as the "Toilet Fairy" from high school while hanging out in Yaniko's room. Hameko visits the city hall to give herself an official surname, "Easygoing*Angel", and includes the asterisk on her submitted form, leading a confused clerk to interpret it as "Easygoing Anal Angel".

Yaniko spills tar juice on herself and her landlord. Yaniko accidentally spills cigarettes from a new pack on the ground. Yaniko tries to work at a few part-time jobs but her chainsmoking angers her employers. Yaniko is forced to live on a few hundred yen and six cigarettes for a week. Yaniko calls her sister, Imoko. Yaniko uses multiple nicotine patches at once. Yaniko blows a smoke ring in the shape of a heart. Yaniko's smoke reminds the Landlord of his abusive father. Yaniko takes a bath and falls asleep naked, making herself sick. Imoko visits Yaniko's apartment in a hazmat suit to nurse her back to health. Yaniko has a nightmare about a doctor visit that makes her promise to quit smoking to Imoko, only to get inspired to smoke again by seeing the Milky Way.