In a whirlwind narrative of vanity and conceit, Can't Lose You is the story of two characters who come from opposite worlds but are united by the most unlikely of circumstances: Yooi is a desperate girl working day and night to earn pennies in hopes of one day paying off her father's debts.

Lida comes from privilege and excess, the heiress to an unbelievable fortune and a marriage match she cannot wait to consummate. But when the two girls meet and discover the one thing they have in common is their identical faces their lives take an unexpected turn. As Yooi accepts the irresistible offer of becoming Lida's double, she finds herself in over her head, being chased by assassins and falling head over heels for Lida's fiancé. Meanwhile, Lida is completely unaware of the shocking revelation awaiting her.