Jisatsu Circle is a manga based on a movie of the same title, written and directed by Sion Sono. At first, the manga was intended to follow the same story, but Sion Sono asked Usamaru Furuya to adapt his own story to it, which resulted in a plot much easier to understand.

The story begins with the same opening scene, where 54 girls commit suicide by jumping in front of a moving train. However, one girl survives (Saya Kota) and opens another Suicide Club, with other victims. Her best friend, Kyoko, fears for Saya's future and begins to search for the strange secrets surrounding the Suicide Club to try and save Saya and the other girls from committing such a tragedy again.