In the near future, Japan is divided and ruled by Russia and China. The latter, in order to overpower Russia, has been secretly experimenting with a biological weapon, code-named "Wolf". However, one night, 49 experimental subjects that were being kept by the Chinese escaped from the laboratory in which they were held, putting a demilitarised zone near the broder under siege.

A Chinese special forces, sent to destroy the evidence. The Russians, who want to get hold of the subjects. The wolves, biological weapons who just want to survive. From now on, their destinies are intertwined.