Sasameki Koto is the story of Murasame Sumika, an intelligent and athletically gifted girl who just happens to be in love with her best friend, Kazama Ushio. Unable to confess her feelings, Sumika can only stay by her side and watch over her. After all, the biggest obstacle to her love is something that she can't change. It has nothing to do with the fact they're both girls; Sumika just isn't Kazama's type!

Kazama is only into cute girls and Sumika's cool personality just doesn't fit the bill. Much to her friend's dismay, Kazama is always eager to share news about her latest crush. With the duo's knack for attracting trouble, it looks like Sumika's trials have only just begun.