Peter Parker is on the outs with the Avengers, the Fantastic Four and even Aunt May! But what did Spider-Man do that has alienated him from everyone? And what’s going on with Peter and Mary Jane? Doctor Octopus is out to get his archnemesis, the Master Planner is unleashing fresh schemes and the gangster called Tombstone is masking some shocking moves that will culminate in a truly brutal showdown! Somebody from Spidey’s past captures the Sinister Six and uses them to create the truly terrifying Sinister Adaptoid! Norman Osborn returns to shake up the status quo! Tragedy strikes when a young hero falls! And Marvel’s two most infamous clones — Ben Reilly and Madelyne Pryor — unite to spin a Dark Web that ensnares Spidey and the X-Men!