On her 21st birthday, Zatanna Zatara—assistant to the most talented magician in the world—is attacked and bested by a mysterious sorceress. Before the final blow is dealt, her father, Giovanni, casts a spell of his own, warping the magic of his attacker and sending Zatanna out of the frying pan and into ye olde garbage bin.

Zatanna arrives in Whitechapel, London, in the year 1888. She soon discovers a serial killer plaguing the streets of the city, Jack the Ripper. Unable to return home and certain that the supernatural killer has answers, Zatanna sets out in pursuit of the Ripper alongside the denizens of Whitechapel and one John Constantine.