Higeneko

At the end of summer, Eiji Aono witnesses his childhood friend and girlfriend, Miyuki Amada, cheating on him with Kondo, the ace of the soccer team. Betrayed by her and emotionally shattered, Eiji becomes the target of baseless slander and harassment. Cornered and with nowhere to turn, he escapes to the school rooftop—where he meets a mysterious girl...

(MTL'd from Publisher's website) A "failure" with 0 (zero) evaluation, 0 (zero) performance, and 0 (zero) confidence causes a whirlwind in the world of alchemy...? Born into a family of alchemists, Sasha was shunned by her family. However, although she is not aware of it herself, she actually has a talent for alchemy... Although she was kicked out of her home, she was scouted by the prince of a neighboring country and became an alchemist in the hands of the state!?